Binaltorphimine - Binaltorphimine

Binaltorphimine
Klinické údaje

ATC kód	Žádný
Identifikátory
Název IUPAC (1S,2S,7S,8R,12S,20R,24R,32R) -11,33-bis (cyklopropylmethyl) -22-methyl-19,25-dioxa-11,22,33-triazaundekacyklo [24.9.1.1^8,14.0^1,24.0^2,32.0^4,23.0^5,21.0^7,12.0^8,20.0^18,37.0^30,36] Heptatriaconta-4 (23), 5 (21), 14 (37), 15,17,26 (36), 27,29-oktaen-2,7,17,27-tetrol
Číslo CAS	105618-27-7^Y
PubChem CID	5484197
ChemSpider	24673307
UNII	94L0JAS27S
ChEMBL	ChEMBL610001
Řídicí panel CompTox (EPA)	DTXSID90909634
Chemické a fyzikální údaje
Vzorec	C₄₁H₄₅N₃Ó₆
Molární hmotnost	675.826 g · mol⁻¹
3D model (JSmol )	Interaktivní obrázek
ÚSMĚVY CN1C2 = C (C [C]] 3 ([CH] 4CC5 = C6 [C]] 3 ([CH] 2OC6 = C (C = C5) O) CCN4CC7CC7) O) C8 = C1 [C @ H] 9 [C @@] 12CCN ([C @ H] ([C @] 1 (C8) O) CC1 = C2C (= C (C = C1) O) O9) CC1CC1
InChI InChI = 1S / C41H45N3O6 / c1-42-32-24 (16-40 (47) 28-14-22-6-8-26 (45) 34-30 (22) 38 (40,36 (32) 49- 34) 10-12-43 (28) 18-20-2-3-20) 25-17-41 (48) 29-15-23-7-9-27 (46) 35-31 (23) 39 ( 41,37 (50-35) 33 (25) 42) 11-13-44 (29) 19-21-4-5-21 / h6-9,20-21,28-29,36-37,45- 48H, 2-5,10-19H2,1H3 / t28-, 29-, 36 +, 37 +, 38 +, 39 +, 40-, 41- / m1 / s1 Klíč: DKIVQMBUHVYDFC-IWRYZOJTSA-N

Binaltorphimine (BNI) je selektivní antagonista z κ-opioidní receptor (KOR).^[1] BNI a norbinaltorphimine (nor-BNI) byli prvními vysoce selektivními antagonisty KOR, které se objevily.^[1]

Viz také

Reference

^ ^A ^b Portoghese PS, Lipkowski AW, Takemori AE (březen 1987). „Binaltorphimine and nor-binaltorphimine, potent and selective kappa-opioid receptor antagonists“. Life Sci. 40 (13): 1287–92. doi:10.1016/0024-3205(87)90585-6. PMID 2882399.

Opioidní receptor modulátory
MOR	Agonisté (zkráceně; viz tady úplný seznam): 3-HO-PCP 7-acetoxymitragynin 7-Hydroxymitragynin ψ-Akuammigin α-chlornaltrexamin α-narkotin Acetyldihydrokodein Acetylfentanyl Acrylfentanyl Adrenorfin (metorfamid) AH-7921 Akuammicin Akuammidin Alfentanil Anileridin Apparicine β-endorfin BAM-12P BAM-18P BAM-22P Benzhydrokodon Benzylmorfin Bezitramid Bifalin BU08070 Buprenorfin Butorfan Butorfanol Butyrfentanyl BW373U86 Carfentanil Kasokefamid Cebranopadol Chloroxymorfamin Kodein DADLE DAMGO (DAGO) Dermorfin Desmetramadol (desmethyltramadol) Desomorfin Dextromoramid Dextropropoxyfen (propoxyfen) Dezocine Dimenoxadol Dimethylaminopivalofenon Eluxadolin Diamorphine (heroin) Dihydrokodein Dihydroetorfin Dihydromorfin Dinalbuphin sebakát Difenoxylát Dipipanon Dynorphin A Embutramid Endomorfin-1 Endomorfin-2 Eseroline Ethylmorfin Etorphine Fentanyl Fluorofen Frakefamid Furanylfentanyl Hemorfin-4 Herkinorin Hodgkinsine Hydrokodon Hydromorfinol Hydromorfon IBNtxA Ketamin Ketobemidon Kratom Laudanosin Lefetamin Leu-enkefalin Levacetylmethadol Levomethorfan Levorfanol Lexanopadol Loperamid Loxikodegol Matrine Meptazinol Met-enkefalin (metenkefalin) Metadon Metkefamid Metopon Mitragynin Mitragynin pseudoindoxyl Morficeptin Morfium Nalbuphine NalBzOH Nalmexon Naltalimid Neopin NFEPP Nikokodein Nikodikodin Nikomorfin NKTR-181 Norketamin Oktreotid Oliceridin OM-3-MNZ Oripavin Oxykodon Oxymorfazon Oxymorfonazin Oxymorfon Oxymorfon fenylhydrazon OxyPNPH Papaver somniferum (opium ) Pentazocin Pericin Petidin (meperidin) Fenazocin Fencyklidin Piminodin Piritramid PL-017 Prodine Propiram PZM21 Racemethorfan Racemorfan Remifentanil Salsolinol SC-17599 Sinomenine Sufentanil Tapentadol Tetrahydropapaverolin TH-030418 Thebaine Thienorfin Tianeptin Tilidin Tramadol Trimebutin TRIMU 5 TRV734 Tubotaiwine U-47700 Valorphin Viminol Xorfanol PAM: BMS-986121 BMS-986122 Antagonisté: (3S, 4S) -picenadol 2- (S) -N, N- (R) -Viminol 3CS-nalmefen 4-Caffeoyl-1,5-chinid 4'-hydroxyflavanon 4 ', 7-dihydroxyflavon 6p-Naltrexol 6β-Naltrexol-d4 18-MC a-gliadin β-chlornaltrexamin β-Funaltrexamin Akuammin Alvimopan AM-251 Apigenin AT-076 Axelopran Bevenopran Katechin Katechin gallát Clocinnamox CTAP CTOP Cyclofoxy Cyprodime Diacetylnalorfin Diprenorfin EKG EGC Epikatechin Eptazocin Gemazocin Ginsenosid R. Hyperosid Ibogain Levallorfan Lobeline LY-255582 LY-2196044 Methocinnamox Methylnaltrexon Methylsamidorfan chlorid Naldemedine Nalmefen Nalodein (N-allylnorkodein) Nalorfin Nalorfin dinikotinát Naloxazon Naloxegol Naloxol Naloxonazin Naloxon Naltrexazon Naltrexonazin Naltrexon Naltrindol Naringenin Noribogain Oxilorfan Pawhuskin A Rimonabant Quadazocin Samidorfan Taxifolin Neznámý / netříděný: Cannabidiol Koronaridin Cyproteron-acetát Dihydroakuuamin Tabernanthin Tetrahydrokanabinol
DOR	Agonisté: 3CS-nalmefen 6'-GNTI 7-SIOM ADL-5747 (PF-04856881) ADL-5859 Alazocin (SKF-10047) Amoxapin AR-M100390 (ARM390) AZD2327 β-endorfin BAM-18P Bifalin BU-48 Butorfan Butorfanol BW373U86 Kasokefamid Cebranopadol Kodein Cyklazocin DADLE Deltorphin A Deltorphin I. Deltorphin II Desmethylklozapin Desmetramadol (desmethyltramadol) Dezocine Diamorphine (heroin) Dihydroetorfin Dihydromorfin DPDPE DPI-221 DPI-3290 DSLET Ethylketazocin Etorphine Fentanyl VEJÍT SE Fluorofen Hemorfin-4 Hydrokodon Hydromorfon Ibogain Isomethadon JNJ-20788560 KNT-127 Kratom Laudanosin Leu-enkefalin Levomethorfan Levorfanol Lexanopadol Lofentanil Met-enkefalin (metenkefalin) Metazocin Metkefamid Mitragynin Mitragynin pseudoindoxyl Morfium N-fenethyl-14-ethoxymetopon Norbuprenorfin NalBzOH Oripavin Oxykodon Oxymorfon Petidin (meperidin) Proglumid Racemethorfan Racemorfan RWJ-394674 Samidorfan SB-235863 SNC-80 SNC-162 TAN-67 (SB-205,607) TH-030418 Thebaine Thiobromadol (C-8813) Tonazocin Tramadol TRV250 Xorfanol Zenazocin Antagonisté: 4 ', 7-dihydroxyflavon 5'-NTII 6p-Naltrexol 6β-Naltrexol-d4 a-Santolol β-chlornaltrexamin Apigenin AT-076 Axelopran Bevenopran BNTX Katechin Katechin gallát Clocinnamox Diacetylnalorfin Diprenorfin EKG EGC Eluxadolin Epikatechin ICI-154129 ICI-174864 LY-255582 LY-2196044 Methylnaltrexon Methylnaltrindol N-benzylnaltrindol Nalmefen Nalorfin Naltrexon Naltriben Naltrindol Naloxon Naringenin Noribogain Pawhuskin A Quadazocin SDM25N SoRI-9409 Taxifolin Thienorfin Neznámý / netříděný: 18-MC Cannabidiol Koronaridin Cyproteron-acetát Tabernanthin Tetrahydrokanabinol
KOR	Agonisté: 3CS-nalmefen 6'-GNTI 8-CAC 18-MC 14-methoxymetopon β-chlornaltrexamin β-Funaltrexamin Adrenorfin (metorfamid) Akuuamicin Alazocin (SKF-10047) Alomatrin Apadoline Asimadolin BAM-12P BAM-18P BAM-22P Velký dynorphin Bremazocin BRL-52537 Butorfan Butorfanol BW373U86 Cebranopadol Ciprefadol CR665 Cyklazocin Cyklofan Cyprenorfin Desmetramadol (desmethyltramadol) Diamorphine (heroin) Diacetylnalorfin Difelikefalin Dihydroetorfin Dihydromorfin Dinalbuphin sebakát Diprenorfin Dynorphin A Dynorfin B (rimorfin) Eluxadolin Enadoline Eptazocin Erinacin E Ethylketazocin Etorphine Fedotozin Fentanyl Gemazocin GR-89696 GR-103545 Hemorfin-4 Herkinorin HS665 Hydromorfon HZ-2 Ibogain ICI-199,441 ICI-204,448 Ketamin Ketazocin Laudanosin Leumorfin (dynorphin B-29) Levallorfan Levomethorfan Levorfanol Lexanopadol Lofentanil LPK-26 Lufuradom Matrine MB-1C-OH Mentol Metazocin Metkefamid Mianserin Mirtazapin Morfium Moxazocin MR-2034 N-MPPP Nalbuphine NalBzOH Nalfurafin Nalmefen Nalodein (N-allylnorkodein) Nalorfin Naltriben Niravoline Norbuprenorfin Norbuprenorfin-3-glukuronid Noribogain Norketamin Oripavin Oxilorfan Oxykodon Pentazocin Petidin (meperidin) Fenazocin Proxorfan Racemethorfan Racemorfan RB-64 Salvinorin A (salvia ) Salvinorin B ethoxymethylether Salvinorin B methoxymethylether Samidorfan Spiradolin (U-62 066) TH-030418 Thienorfin Tifluadom Tricyklická antidepresiva (např., amitriptylin, desipramin, imipramin, nortriptylin ) U-50488 U-54,494A U-69 593 Xorfanol Antagonisté: 4'-hydroxyflavanon 4 ', 7-dihydroxyflavon 5'-GNTI 6'-GNTI 6p-Naltrexol 6β-Naltrexol-d4 β-chlornaltrexamin Buprenorfin / samidorfan Amentoflavon PROTI Apigenin Arodyne AT-076 Atikant Axelopran AZ-MTAB Binaltorphimine BU09059 Buprenorfin Katechin Katechin gallát CERC-501 (LY-2456302) Clocinnamox Cyclofoxy Dezocine DIPPA EGC EKG Epikatechin Hyperosid JDTic LY-255582 LY-2196044 LY-2444296 LY-2459989 LY-2795050 MeJDTic Methylnaltrexon ML190 ML350 MR-2266 N-fluorpropyl-JDTic Naloxon Naltrexon Naltrindol Naringenin Norbinaltorphimine Noribogain Pawhuskin A PF-4455242 RB-64 Quadazocin Taxifolin UPHIT Zyklophin Neznámý / netříděný: Akuammicin Akuammin Koronaridin Cyproteron-acetát Dihydroakuuamin Ibogamin Tabernanthin
NOP	Agonisté: (Arg14, Lys15) Nociceptin ((pF) Phe⁴) Nociceptin (1-13) NH₂ (Phe¹Ψ (CH₂-NH) Gly²) Nociceptin (1-13) NH₂ Ac-RYYRWK-NH₂ Ac-RYYRIK-NH₂ BU08070 Buprenorfin Cebranopadol Dihydroetorfin Etorphine JNJ-19385899 Levomethorfan Levorfanol Levorfanol Lexanopadol MCOPPB MT-7716 NNC 63-0532 Nociceptin (orphanin FQ) Nociceptin (1-11) Nociceptin (1-13) NH₂ Norbuprenorfin Racemethorfan Racemorfan Ro64-6198 Ro65-6570 SCH-221510 SCH-486757 SR-8993 SR-16435 TH-030418 Antagonisté: (Nphe¹) Nociceptin (1-13) NH₂ AT-076 BAN-ORL-24 BTRX-246040 (LY-2940094) J-113 397 JTC-801 NalBzOH Nociceptin (1-7) Nocistatin SB-612,111 SR-16430 Thienorfin Trap-101 UFP-101
Netříděný	β-kazomorfiny Amidorfin BAM-20P Cytochrophin-4 Deprolorphin Gliadorphin (gluteomorphin) Lepkové exorfiny Hemorfiny Kava složky MEAGL MEAP NEM Neoendorfiny Nepetalakton (catnip ) Peptid B. Peptid E. Peptid F Peptid I. Rubiscoliny Soymorfiny
Ostatní	Inhibitory enkefalinázy: Amastatin BL-2401 Kandoxatril D -Fenylalanin Dexecadotril (retorfan) Ecadotril (sinorfan) Kelatorphan Racecadotril (acetorfan) RB-101 RB-120 RB-3007 Opiorfan Selank Semax Spinorfin Thiorphan Tynorphin Ubenimex (bestatin) Propeptidy: β-lipotropin (proendorfin) Prodynorphin Proenkefalin Pronociceptin Proopiomelanokortin (POMC) Ostatní: Kyotorphin (uvolňovač met-enkefalinu / stabilizátor degradace)
Viz také: Receptorové / signalizační modulátory • Signální modulátory peptid / proteinový receptor

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