Seznam kanabinoidů JWH - List of JWH cannabinoids - Wikipedia
The John W. Huffman výzkumná skupina v Clemson University syntetizováno přes 450 kanabinoidy.[1][2][3][4] Některé z nich jsou:
| název | Třída | K.i / nM ve společnosti CB1 | K.i / nM ve společnosti CB2 | Selektivita | Struktura |
|---|---|---|---|---|---|
| JWH-004 | Naftoylindol | 48 ± 13 | 4 ± 1.5 | CB2 (12x) |  |
| JWH-007[5] | Naftoylindol | 9.5 ± 4.5 | 2.9 ± 2.6 | CB2 (3,3x) |  |
| JWH-009 | Naftoylindol | >10000 | 141 ± 14 | CB2 (> 70x) |  |
| JWH-011 | Naftoylindol |  | |||
| JWH-015[5] | Naftoylindol | 164 ± 22 | 13.8 ± 4.6 | CB2 (12x) |  |
| JWH-016 | Naftoylindol | 22 ± 1.5 | 4.3 ± 1.6 | CB2 (5,1x) |  |
| JWH-018[5] | Naftoylindol | 9 ± 5 | 2.9 ± 2.6 | CB2 (3,1x) |  |
| JWH-019 | Naftoylindol | 9.8 ± 2 | 5.55 ± 2 | CB2 (1,77x) |  |
| JWH-020 | Naftoylindol | 128 ± 17 | 205 ± 20 | CB1 (1,6x) |  |
| JWH-030 | Naftoylpyrol | 87 ± 3 | 320 ± 127 | CB1 (3,7x) |  |
| JWH-031 | Naftoylpyrol | 399 ± 109 |  | ||
| JWH-032 | Naftoylpyrol | >10000 | >10000 | — |  |
| JWH-033 | Naftoylpyrol | 666 ± 77 |  | ||
| JWH-036 | Naftoylpyrol | 309 ± 11 |  | ||
| JWH-042[6] | Naftoylindol | >10000 | 5050 ± 192 | CB2 |  |
| JWH-043[6] | Naftoylindol | 1180 ± 44 | 964 ± 242 | CB2 (1,2x) |  |
| JWH-044 | Naftoylpyrol | >10000 | >10000 | — |  |
| JWH-045 | Naftoylpyrol | >10000 | >10000 | — |  |
| JWH-046[6] | Naftoylindol | 343 ± 38 | 16.3 ± 4.9 | CB2 (21x) |  |
| JWH-047[6] | Naftoylindol | 59 ± 3 | 3.47 ± 1.80 | CB2 (17x) |  |
| JWH-048[6] | Naftoylindol | 10.7 ± 1.0 | 0.49 ± 0.13 | CB2 (22x) |  |
| JWH-049[6] | Naftoylindol | 55.1 ± 17.0 | 32.3 ± 2.4 | CB2 (1,7x) |  |
| JWH-050[6] | Naftoylindol | 342 ± 6 | 526 ± 133 | CB1 (1,5x) |  |
| JWH-051 | Dibenzopyran | 1.20 | 0.03 | CB2 (40x) |  |
| JWH-056[7] | Dibenzopyran | >10000 | 32 ± 9 | CB2 |  |
| JWH-057[8] | Dibenzopyran | 23 ± 7 | 2.9 ± 1.6 | CB2 (8x) |  |
| JWH-065[7] | Dibenzopyran | 399 ± 76 | 10 ± 2 | CB2 (40x) |  |
| JWH-070[6] | Naftoylindol | >10000 | >10000 |  | |
| JWH-071[6] | Naftoylindol | 1340 ± 123 | 2940 ± 852 | CB1 (2,2x) |  |
| JWH-072 | Naftoylindol | 1050 ± 5.5 | 170 ± 54 | CB2 (6x) |  |
| JWH-073 | Naftoylindol | 8.9 ± 1.8 | 27 ± 12 | CB1 (3x) |  |
| JWH-076[5] | Naftoylindol | 214 ± 11 | 106 ± 46 | CB2 (2x) |  |
| JWH-077[6] | Naftoylindol | >10000 | >10000 |  | |
| JWH-078[6] | Naftoylindol | 817 ± 60 | 633 ± 116 | CB2 (1,3x) |  |
| JWH-079[6] | Naftoylindol | 63.0 ± 3.0 | 32.0 ± 6.0 | CB2 (2x) |  |
| JWH-080[6] | Naftoylindol | 8.9 ± 1.8 | 2.21 ± 1.30 | CB2 (4x) |  |
| JWH-081[6] | Naftoylindol | 1.2 ± 0.03 | 12.4 ± 2.2 | CB1 (10x) |  |
| JWH-082[6] | Naftoylindol | 5.3 ± 0.8 | 6.40 ± 0.94 | CB1 (1,2x) |  |
| JWH-083[6] | Naftoylindol | 106 ± 12 | 102 ± 50 | — |  |
| JWH-091[9] (Δ8-THCP ) | Dibenzopyran | 22.0 ± 3.9 |  | ||
| JWH-093[6] | Naftoylindol | 40.7 ± 2.8 | 59.1 ± 10.5 | CB1 (1,45x) |  |
| JWH-094[6] | Naftoylindol | 476 ± 67 | 97.3 ± 2.7 | CB2 (4,9x) |  |
| JWH-095[6] | Naftoylindol | 140 ± 4.3 | 312 ± 83 | CB1 (2,2x) |  |
| JWH-096[6] | Naftoylindol | 33.7 ± 2.9 | 13.3 ± 5.6 | CB2 (2,5x) |  |
| JWH-097[6] | Naftoylindol | 455 ± 28 | 121 ± 15 | CB2 (3,8x) |  |
| JWH-098[6] | Naftoylindol | 4.5 ± 0.1 | 1.9 ± 0.3 | CB2 (2,4x) |  |
| JWH-099[6] | Naftoylindol | 35.3 ± 9.0 | 17.8 ± 2.9 | CB2 (2x) |  |
| JWH-100[6] | Naftoylindol | 381 ± 102 | 155 ± 74 | CB2 (2,5x) |  |
| JWH-102[7] | Dibenzopyran | 7.9 ± 0.9 | 5.2 ± 2.0 | CB2 (1,5x) |  |
| JWH-103[7] | Dibenzopyran | 28 ± 3 | 23 ± 7 | CB2 (1,2x) |  |
| JWH-116[10] | Naftoylindol | 52 ± 5 |  | ||
| JWH-120[5] | Naftoylindol | 1054 ± 31 | 6.1 ± 0.7 | CB2 (173x) |  |
| JWH-122[10] | Naftoylindol | 0.69 ± 0.05 | 1.2 ± 1.2 | — |  |
| JWH-124 (Δ8-Parahexyl ) | Dibenzopyran | 41.0 ± 3.8 |  | ||
| JWH-130 (Δ8-THCB ) | Dibenzopyran | 65.0 ± 13 |  | ||
| JWH-133[7] | Dibenzopyran | 677 ± 132 | 3.4 ± 1.0 | CB2 (200x) |  |
| JWH-138[11] | Dibenzopyran | 8.5 ± 1.4 |  | ||
| JWH-139[12] | Dibenzopyran | 2290 ± 505 | 14 ± 10 | CB2 (164x) |  |
| JWH-142[7] | Dibenzopyran | 529 ± 49 | 35 ± 14 | CB2 (15x) |  |
| JWH-143[7] | Dibenzopyran | 924 ± 104 | 65 ± 8 | CB2 (14x) |  |
| JWH-145[13] | Naftoylpyrol | 14 ± 2 | 6.4 ± 0.4 | CB2 (2,2x) |  |
| JWH-146[13] | Naftoylpyrol | 21 ± 2 | 62 ± 5 | CB2 (3,0x) |  |
| JWH-147[13] | Naftoylpyrol | 11 ± 1 | 7.1 ± 0.2 | CB2 (1,5x) |  |
| JWH-148[5] | Naftoylindol | 123 ± 8 | 14.0 ± 1.0 | CB2 (8x) |  |
| JWH-149[5] | Naftoylindol | 5.0 ± 2.1 | 0.73 ± 0.03 | CB2 (6,8x) |  |
| JWH-150[13] | Naftoylpyrol | 60 ± 1 | 15 ± 2 | CB2 (4x) |  |
| JWH-151[5] | Naftoylindol | >10000 | 30 ± 1.1 | CB2 (> 333x) |  |
| JWH-153[5] | Naftoylindol | 250 ± 24 | 11 ± 0.5 | CB2 (23x) |  |
| JWH-156[13] | Naftoylpyrol | 404 ± 18 | 104 ± 18 | CB2 (4x) |  |
| JWH-159[5] | Naftoylindol | 45 ± 1 | 10.4 ± 1.4 | CB2 (4,3x) |  |
| JWH-160[5] | Naftoylindol | 1568 ± 201 | 441 ± 110 | CB2 (3,6x) |  |
| JWH-161 | Dibenzopyranový hybrid | 19.0 |  | ||
| JWH-163[5] | Naftoylindol | 2358 ± 215 | 138 ± 12 | CB2 (17x) |  |
| JWH-164[5] | Naftoylindol | 6.6 ± 0.7 | 6.9 ± 0.2 | — |  |
| JWH-165[5] | Naftoylindol | 204 ± 26 | 71 ± 8 | CB2 (2,9x) |  |
| JWH-166[5] | Naftoylindol | 44 ± 10 | 1.9 ± 0.08 | CB2 (23x) |  |
| JWH-167 | Fenylacetylindol | 90 ± 17 | 159 ± 14 | CB1 (1,77x) |  |
| JWH-171 | Uhlovodík | 51 |  | ||
| JWH-175[10] | Naftylmethylindol | 22 ± 2 |  | ||
| JWH-176[10] | Uhlovodík | 26 ± 4 |  | ||
| JWH-180[5] | Naftoylindol | 26 ± 2 | 9.6 ± 2.0 | CB2 (2,7x) |  |
| JWH-181[5] | Naftoylindol | 1.3 ± 0.1 | 0.62 ± 0.04 | CB2 (2,1x) |  |
| JWH-182[5] | Naftoylindol | 0.65 ± 0.03 | 1.1 ± 0.1 | CB1 (1,7x) |  |
| JWH-184[10] | Naftylmethylindol | 23 ± 6 |  | ||
| JWH-185[10] | Naftylmethylindol | 17 ± 3 |  | ||
| JWH-186[14] | Dibenzopyran | 187 ± 23 | 5.6 ± 1.7 | CB2 (33x) |  |
| JWH-187[14] | Dibenzopyran | 84 ± 16 | 3.4 ± 0.5 | CB2 (25x) |  |
| JWH-188[14] | Dibenzopyran | 270 ± 58 | 18 ± 2 | CB2 (15x) |  |
| JWH-189[5] | Naftoylindol | 52 ± 2 | 12 ± 0.8 | CB2 (4,3x) |  |
| JWH-190[14] | Dibenzopyran | 8.8 ± 1.4 | 1.6 ± 0.03 | CB2 (5,5x) |  |
| JWH-191[14] | Dibenzopyran | 1.8 ± 0.3 | 0.52 ± 0.03 | CB2 (3,5x) |  |
| JWH-192[10] | Naftylmethylindol | 41 ± 13 |  | ||
| JWH-193[10] | Naftoylindol | 6 ± 1 |  | ||
| JWH-194[10] | Naftylmethylindol | 127 ± 19 |  | ||
| JWH-195[10] | Naftylmethylindol | 113 ± 28 |  | ||
| JWH-196[10] | Naftylmethylindol | 151 ± 18 |  | ||
| JWH-197[10] | Naftylmethylindol | 323 ± 98 |  | ||
| JWH-198[10] | Naftoylindol | 10 ± 2 |  | ||
| JWH-199[10] | Naftylmethylindol | 20 ± 2 |  | ||
| JWH-200[10] | Naftoylindol | 42 ± 5 |  | ||
| JWH-201[15] | Fenylacetylindol | 1064 ± 21 | 444 ± 14 | CB2 (2,4x) |  |
| JWH-202[15] | Fenylacetylindol | 1678 ± 63 | 645 ± 6 | CB2 (2,6x) |  |
| JWH-203[15] | Fenylacetylindol | 8.0 ± 0.9 | 7.0 ± 1.3 | — |  |
| JWH-204[15] | Fenylacetylindol | 13 ± 1 | 25 ± 1 | CB1 (1,9x) |  |
| JWH-205[15] | Fenylacetylindol | 124 ± 23 | 180 ± 9 | CB1 (1,45x) |  |
| JWH-206[15] | Fenylacetylindol | 389 ± 25 | 498 ± 37 | CB1 (1,28x) |  |
| JWH-207[15] | Fenylacetylindol | 1598 ± 134 | 3723 ± 10 | CB1 (2,33x) |  |
| JWH-208[15] | Fenylacetylindol | 179 ± 7 | 570 ± 127 | CB1 (3,18x) |  |
| JWH-209[15] | Fenylacetylindol | 746 ± 49 | 1353 ± 270 | CB1 (1,81x) |  |
| JWH-210[5] | Naftoylindol | 0.46 ± 0.03 | 0.69 ± 0.01 | CB1 (1,5x) |  |
| JWH-211[5] | Naftoylindol | 70 ± 0.8 | 12 ± 0.8 | CB2 (5,8x) |  |
| JWH-212[5] | Naftoylindol | 33 ± 0.9 | 10 ± 1.2 | CB2 (3,3x) |  |
| JWH-213[5] | Naftoylindol | 1.5 ± 0.2 | 0.42 ± 0.05 | CB2 (3,6x) |  |
| JWH-215[14] | Dibenzopyran | 1008 ± 117 | 85 ± 21 | CB2 (12x) |  |
| JWH-216[14] | Dibenzopyran | 1856 ± 148 | 333 ± 104 | CB2 (5,6x) |  |
| JWH-217[14] | Dibenzopyran | >10000 | 1404 ± 66 | CB2 (> 7x) |  |
| JWH-220 | Uhlovodík | 19 |  | ||
| JWH-224[14] | Dibenzopyran | 347 ± 34 | 28 ± 1 | CB2 (12,3x) |  |
| JWH-225[14] | Dibenzopyran | >10000 | 325 ± 70 | CB2 (> 31x) |  |
| JWH-226[14] | Dibenzopyran | 4001 ± 282 | 43 ± 3 | CB2 (93x) |  |
| JWH-227[14] | Dibenzopyran | 40 ± 6 | 4.4 ± 0.3 | CB2 (9x) |  |
| JWH-229[16] | Dibenzopyran | 3134 ± 110 | 18 ± 2 | CB2 (174x) |  |
| JWH-230[14] | Dibenzopyran | 15 ± 3 | 1.4 ± 0.12 | CB2 (10,7x) |  |
| JWH-233[14] | Dibenzopyran | 14 ± 3 | 1.0 ± 0.3 | CB2 (14x) |  |
| JWH-234[5] | Naftoylindol | 8.4 ± 1.8 | 3.8 ± 0.6 | CB2 (2,2x) |  |
| JWH-235[5] | Naftoylindol | 338 ± 34 | 123 ± 34 | CB2 (2,7x) |  |
| JWH-236[5] | Naftoylindol | 1351 ± 204 | 240 ± 63 | CB2 (5,6x) |  |
| JWH-237[15] | Fenylacetylindol | 38 ± 10 | 106 ± 2 | CB1 (2,8x) |  |
| JWH-239[5] | Naftoylindol | 342 ± 20 | 52 ± 6 | CB2 (6,6x) |  |
| JWH-240[5] | Naftoylindol | 14 ± 1 | 7.2 ± 1.3 | CB2 (1,9x) |  |
| JWH-241[5] | Naftoylindol | 147 ± 20 | 49 ± 7 | CB2 (3,0x) |  |
| JWH-242[5] | Naftoylindol | 42 ± 9 | 6.5 ± 0.3 | CB2 (6,5x) |  |
| JWH-243[13] | Naftoylpyrol | 285 ± 40 | 41 ± 3 | CB2 (6,95x) |  |
| JWH-244[13] | Naftoylpyrol | 130 ± 6 | 18 ± 1 | CB2 (7,22x) |  |
| JWH-245[13] | Naftoylpyrol | 276 ± 4 | 25 ± 2 | CB2 (11x) |  |
| JWH-246[13] | Naftoylpyrol | 70 ± 4 | 16 ± 1 | CB2 (4,38x) |  |
| JWH-247[14] | Dibenzopyran | 427 ± 31 | 99 ± 4 | CB2 (4,3x) |  |
| JWH-248[15] | Fenylacetylindol | 1028 ± 39 | 657 ± 19 | CB2 (1,56x) |  |
| JWH-249[15] | Fenylacetylindol | 8.4 ± 1.8 | 20 ± 2 | CB1 (2,38x) |  |
| JWH-250[15] | Fenylacetylindol | 11 ± 2 | 33 ± 2 | CB1 (3x) |  |
| JWH-251[15] | Fenylacetylindol | 29 ± 3 | 146 ± 36 | CB2 (5x) |  |
| JWH-252[15] | Fenylacetylindol | 23 ± 3 | 19 ± 1 | CB2 (1,2x) |  |
| JWH-253[15] | Fenylacetylindol | 62 ± 10 | 84 ± 12 | CB1 (1,35x) |  |
| JWH-254[14] | Dibenzopyran | 4724 ± 509 | 319 ± 16 | CB2 (14,8x) |  |
| JWH-256[14] | Dibenzopyran | 4300 ± 888 | 97 ± 18 | CB2 (44x) |  |
| JWH-258[5] | Naftoylindol | 4.6 ± 0.6 | 10.5 ± 1.3 | CB1 (2,3x) |  |
| JWH-259[5] | Naftoylindol | 220 ± 29 | 74 ± 7 | CB2 (3,0x) |  |
| JWH-260[5] | Naftoylindol | 29 ± 0.4 | 25 ± 1.9 | CB2 (1,2x) |  |
| JWH-261[5] | Naftoylindol | 767 ± 105 | 221 ± 14 | CB2 (3,5x) |  |
| JWH-262[5] | Naftoylindol | 28 ± 3 | 5.6 ± 0.7 | CB2 (5,0x) |  |
| JWH-265[5] | Naftoylindol | 3788 ± 323 | 80 ± 13 | CB2 (47x) |  |
| JWH-266[5] | Naftoylindol | >10000 | 455 ± 55 | CB2 (> 22x) |  |
| JWH-267[5] | Naftoylindol | 381 ± 16 | 7.2 ± 0.14 | CB2 (53x) |  |
| JWH-268[5] | Naftoylindol | 1379 ± 193 | 40 ± 0.6 | CB2 (34x) |  |
| JWH-277[14] | Dibenzopyran | 3905 ± 91 | 589 ± 65 | CB2 (6,6x) |  |
| JWH-278[14] | Dibenzopyran | 906 ± 80 | 69 ± 6 | CB2 (13x) |  |
| JWH-292[13] | Naftoylpyrol | 29 ± 1 | 20 ± 1 | CB2 (1,45x) |  |
| JWH-293[13] | Naftoylpyrol | 100 ± 5 | 41 ± 4 | CB2 (2,44x) |  |
| JWH-298[14] | Dibenzopyran | 812 ± 67 | 198 ± 23 | CB2 (4,1x) |  |
| JWH-299[14] | Dibenzopyran | 415 ± 50 | 30 ± 2 | CB2 (13,8x) |  |
| JWH-300[12] | Dibenzopyran | 118 ± 16 | 5.3 ± 0.1 | CB2 (22x) |  |
| JWH-301[14] | Dibenzopyran | 295 ± 64 | 48 ± 4 | CB2 (6,1x) |  |
| JWH-302[15] | Fenylacetylindol | 17 ± 2 | 89 ± 15 | CB1 (5,26x) |  |
| JWH-303[15] | Fenylacetylindol | 117 ± 10 | 138 ± 12 | CB1 (1,18x) |  |
| JWH-304[15] | Fenylacetylindol | 3363 ± 332 | 2679 ± 688 | CB2 (1,26x) |  |
| JWH-305[15] | Fenylacetylindol | 15 ± 1.8 | 29 ± 5 | CB1 (1,93x) |  |
| JWH-306[15] | Fenylacetylindol | 25 ± 1 | 82 ± 11 | CB1 (3,28x) |  |
| JWH-307[13] | Naftoylpyrol | 7.7 ± 1.8 | 3.3 ± 0.2 | CB2 (2,33x) |  |
| JWH-308[13] | Naftoylpyrol | 41 ± 1 | 33 ± 2 | CB2 (1,24x) |  |
| JWH-309[13] | Naftoylpyrol | 41 ± 3 | 49 ± 7 | CB1 (1,20x) |  |
| JWH-310[14] | Dibenzopyran | 1059 ± 51 | 36 ± 3 | CB2 (29x) |  |
| JWH-311[15] | Fenylacetylindol | 23 ± 2 | 39 ± 3 | CB1 (1,70x) |  |
| JWH-312[15] | Fenylacetylindol | 72 ± 7 | 91 ± 20 | CB1 (1,26x) |  |
| JWH-313[15] | Fenylacetylindol | 422 ± 19 | 365 ± 92 | CB2 (1,16x) |  |
| JWH-314[15] | Fenylacetylindol | 39 ± 2 | 76 ± 4 | CB1 (1,95x) |  |
| JWH-315[15] | Fenylacetylindol | 430 ± 24 | 182 ± 23 | CB2 (3,36x) |  |
| JWH-316[15] | Fenylacetylindol | 2862 ± 670 | 781 ± 105 | CB2 (3,66x) |  |
| JWH-336[12] | Dibenzopyran | 4589 ± 367 | 153 ± 15 | CB2 (30x) |  |
| JWH-338[14] | Dibenzopyran | >10000 | 111 ± 16 | CB2 (> 90x) |  |
| JWH-339[14] | Dibenzopyran | >10000 | 2317 ± 93 | CB2 (> 4,3x) |  |
| JWH-340[14] | Dibenzopyran | 135 ± 6 | 30 ± 1 | CB2 (4,5x) |  |
| JWH-341[14] | Dibenzopyran | 100 ± 8 | 10 ± 0.1 | CB2 (10x) |  |
| JWH-346[13] | Naftoylpyrol | 67 ± 6 | 39 ± 2 | CB2 (1,72x) |  |
| JWH-347[13] | Naftoylpyrol | 333 ± 17 | 169 ± 17 | CB2 (1,97x) |  |
| JWH-348[13] | Naftoylpyrol | 218 ± 19 | 53 ± 1 | CB2 (4,11x) |  |
| JWH-349[14] | Dibenzopyran | 376 ± 1 | 38 ± 4 | CB2 (9,9x) |  |
| JWH-350[12] | Dibenzopyran | 395 ± 50 | 12 ± 1 | CB2 (33x) |  |
| JWH-351[14] | Dibenzopyran | >10000 | 295 ± 3 | CB2 (> 34x) |  |
| JWH-352[14] | Dibenzopyran | >10000 | 47 ± 2 | CB2 (> 213x) |  |
| JWH-353[14] | Dibenzopyran | 1493 ± 10 | 31 ± 1 | CB2 (48x) |  |
| JWH-354[14] | Dibenzopyran | 1961 ± 21 | 241 ± 14 | CB2 (8,1x) |  |
| JWH-355[14] | Dibenzopyran | 2162 ± 220 | 108 ± 17 | CB2 (20x) |  |
| JWH-356[14] | Dibenzopyran | 5837 ± 701 | 108 ± 17 | CB2 (54x) |  |
| JWH-357[14] | Dibenzopyran | 647 ± 78 | 185 ± 4 | CB2 (3,5x) |  |
| JWH-358[14] | Dibenzopyran | 1243 ± 266 | 52 ± 3 | CB2 (24x) |  |
| JWH-359 | Dibenzopyran | 2918 ± 450 | 13.0 ± 0.2 | CB2 (220x) |  |
| JWH-360[14] | Dibenzopyran | 2449 ± 606 | 160 ± 8 | CB2 (15x) |  |
| JWH-361[14] | Dibenzopyran | 63 ± 3 | 2.7 ± 0.1 | CB2 (23x) |  |
| JWH-362[14] | Dibenzopyran | 127 ± 8 | 34 ± 5 | CB2 (3,7x) |  |
| JWH-363[13] | Naftoylpyrol | 245 ± 5 | 71 ± 1 | CB2 (3,45x) |  |
| JWH-364[13] | Naftoylpyrol | 34 ± 3 | 29 ± 1 | CB2 (1,17x) |  |
| JWH-365[13] | Naftoylpyrol | 17 ± 1 | 3.4 ± 0.2 | CB2 (5,0x) |  |
| JWH-366[13] | Naftoylpyrol | 191 ± 12 | 24 ± 1 | CB2 (7,96x) |  |
| JWH-367[13] | Naftoylpyrol | 53 ± 2 | 23 ± 1 | CB2 (2,30x) |  |
| JWH-368[13] | Naftoylpyrol | 16 ± 1 | 9.1 ± 0.7 | CB2 (1,76x) |  |
| JWH-369[13] | Naftoylpyrol | 7.9 ± 0.4 | 5.2 ± 0.3 | CB2 (1,52x) |  |
| JWH-370[13] | Naftoylpyrol | 5.6 ± 0.4 | 4.0 ± 0.5 | CB2 (1,40x) |  |
| JWH-371[13] | Naftoylpyrol | 42 ± 1 | 64 ± 2 | CB1 (1,52x) |  |
| JWH-372[13] | Naftoylpyrol | 77 ± 2 | 8.2 ± 0.2 | CB1 (9,39x) |  |
| JWH-373[13] | Naftoylpyrol | 60 ± 3 | 69 ± 2 | CB1 (1,15x) |  |
| JWH-387[17] | Naftoylindol | 1.2 ± 0.1 | 1.1 ± 0.1 | — |  |
| JWH-398[18] | Naftoylindol | 2.3 ± 0.1 | 2.8 ± 0.2 | CB1 (1,22x) |  |
| JWH-416[17] | Naftoylindol | 73 ± 10 | 3.3 ± 0.1 | CB2 (22x) |  |
| JWH-417[17] | Naftoylindol | 522 ± 58 | 13 ± 0.2 | CB2 (40x) |  |
| JWH-422[17] | Naftoylindol | 501 ± 48 | 20 ± 0.4 | CB2 (25x) |  |
| JWH-423[17] | Naftoylindol | 140 ± 10 | 6.6 ± 0.2 | CB2 (21x) |  |
| JWH-424[17] | Naftoylindol | 21 ± 3.4 | 5.4 ± 0.2 | CB2 (3,9x) |  |
| JWH-425[17] | Naftoylindol | 54 ± 11 | 10 ± 0.4 | CB2 (5,4x) |  |
Viz také
- Seznam AM kanabinoidů
- Seznam CP kanabinoidů
- Seznam HU kanabinoidů
- Seznam různých návrhářských kanabinoidů
Reference
- ^ Manera C, Tuccinardi T, Martinelli A (2008). "Indoly a příbuzné sloučeniny jako kanabinoidní ligandy". Mini Rev Med Chem. 8 (4): 370–87. doi:10.2174/138955708783955935. PMID 18473928.
- ^ Wiley JL, Marusich JA, Huffman JW (2014). „Pohyb po molekule: vztah mezi chemickou strukturou a aktivitou syntetických kanabinoidů in vivo“. Life Sci. 97 (1): 55–63. doi:10.1016 / j.lfs.2013.09.011. PMC 3944940. PMID 24071522.
- ^ Wiley JL, Marusich JA, Thomas BF (2017). „Combination Chemistry: Structure-Activity Relationships of Novel Psychoactive Cannabinoids“. Curr Top Behav Neurosci. Aktuální témata v behaviorálních neurovědách. 32: 231–248. doi:10.1007/7854_2016_17. ISBN 978-3-319-52442-9. PMID 27753007.
- ^ Zábradlí SD, Connor M (2018). „Chemistry and Pharmacology of Synthetic Cannabinoid Receptor Agonists as New Psychoactive Substances: Origins“. Handb Exp Pharmacol. Příručka experimentální farmakologie. 252: 165–190. doi:10.1007/164_2018_143. ISBN 978-3-030-10560-0. PMID 29980914.
- ^ A b C d E F G h i j k l m n Ó str q r s t u proti w X y z aa ab ac inzerát ae af ag ah ai aj ak al dopoledne Huffman JW, Zengin G, Wu MJ, Lu J, Hynd G, Bushell K, Thompson AL, Bushell S, Tartal C, Hurst DP, Reggio PH, Selley DE, Cassidy MP, Wiley JL, Martin BR (leden 2005). "Vztahy mezi strukturou a aktivitou 1-alkyl-3- (1-naftoyl) indolů na kanabinoidních CB (1) a CB (2) receptory: sterické a elektronické účinky naftoylových substituentů. Nové vysoce selektivní agonisty CB (2) receptorů" . Bioorganická a léčivá chemie. 13 (1): 89–112. doi:10.1016 / j.bmc.2004.09.050. PMID 15582455.
- ^ A b C d E F G h i j k l m n Ó str q r s t u proti w X Aung MM, Griffin G, Huffman JW, Wu M, Keel C, Yang B, Showalter VM, Abood ME, Martin BR (srpen 2000). "Vliv délky N-1 alkylového řetězce kanabimimetických indolů na vazbu CB (1) a CB (2) receptoru". Závislost na drogách a alkoholu. 60 (2): 133–40. doi:10.1016 / S0376-8716 (99) 00152-0. PMID 10940540.
- ^ A b C d E F G Huffman JW, Liddle J, Yu S, Aung MM, Abood ME, Wiley JL, Martin BR (prosinec 1999). „3- (1 ', 1'-dimethylbutyl) -1-deoxy-delta8-THC a příbuzné sloučeniny: syntéza selektivních ligandů pro receptor CB2“. Bioorganická a léčivá chemie. 7 (12): 2905–14. doi:10.1016 / s0968-0896 (99) 00219-9. PMID 10658595.
- ^ Huffman JW, Yu S, Showalter V, Abood ME, Wiley JL, Compton DR, Martin BR, Bramblett RD, Reggio PH (září 1996). „Syntéza a farmakologie velmi silného kanabinoidu postrádajícího fenolickou hydroxylovou skupinu s vysokou afinitou k receptoru CB2“. Journal of Medicinal Chemistry. 39 (20): 3875–7. doi:10.1021 / JM960394Y. PMID 8831752.
- ^ Bow EW, Rimoldi JM. Vztahy mezi strukturou a funkcí klasických kanabinoidů: modulace CB1 / CB2. Perspect Medicin Chem. 2016 červen 28; 8: 17-39. doi:10.4137 / PMC.S32171 PMID 27398024
- ^ A b C d E F G h i j k l m n Ó Huffman JW, Mabon R, Wu MJ, Lu J, Hart R, Hurst DP, Reggio PH, Wiley JL, Martin BR (únor 2003). „3-Indolyl-1-naftylmethany: nové kanabimimetické indoly poskytují důkazy o aromatických stohovacích interakcích s kanabinoidním receptorem CB (1)“. Bioorganická a léčivá chemie. 11 (4): 539–49. doi:10.1016 / S0968-0896 (02) 00451-0. PMID 12538019.
- ^ Martin BR, Jefferson R, Winckler R, Wiley JL, Huffman JW, Crocker PJ, Saha B, Razdan RK. Manipulace s postranním řetězcem tetrahydrokanabinolu popisuje agonisty, částečné agonisty a antagonisty. J Pharmacol Exp Ther. Září 1999; 290 (3): 1065-79. PMID 10454479
- ^ A b C d Howlett AC, Barth F, Bonner TI, Cabral G, Casellas P, Devane WA, Felder CC, Herkenham M, Mackie K, Martin BR, Mechoulam R, Pertwee RG (červen 2002). „International Union of Pharmacology. XXVII. Classification of cannabinoid receptors“. Farmakologické recenze. 54 (2): 161–202. doi:10.1124 / pr.54.2.161. PMID 12037135. S2CID 8259002.
- ^ A b C d E F G h i j k l m n Ó str q r s t u proti w X y z aa ab Huffman JW, Padgett LW, Isherwood ML, Wiley JL, Martin BR (říjen 2006). „1-Alkyl-2-aryl-4- (1-naftoyl) pyrroly: nové vysoce afinitní ligandy pro kanabinoidní receptory CB1 a CB2“. Dopisy o bioorganické a léčivé chemii. 16 (20): 5432–5. doi:10.1016 / j.bmcl.2006.07.051. PMID 16889960.
- ^ A b C d E F G h i j k l m n Ó str q r s t u proti w X y z aa ab ac inzerát ae af ag ah ai aj ak al dopoledne Marriott KS, Huffman JW (2008). „Nedávný pokrok ve vývoji selektivních ligandů pro kanabinoidní CB (2) receptor“. Aktuální témata v medicinální chemii. 8 (3): 187–204. doi:10.2174/156802608783498014. PMID 18289088.
- ^ A b C d E F G h i j k l m n Ó str q r s t u proti w X y z aa Huffman JW, Szklennik PV, Almond A, Bushell K, Selley DE, He H, Cassidy MP, Wiley JL, Martin BR (září 2005). „1-Pentyl-3-fenylacetylindoly, nová třída kanabimimetických indolů“. Dopisy o bioorganické a léčivé chemii. 15 (18): 4110–3. doi:10.1016 / j.bmcl.2005.06.008. PMID 16005223.
- ^ Huffman JW, Bushell SM, Miller JR, Wiley JL, Martin BR (prosinec 2002). „1-Methoxy-, 1-deoxy-11-hydroxy- a 11-hydroxy-1-methoxy-Delta (8) -tetrahydrokanabinoly: nové selektivní ligandy pro receptor CB2“. Bioorganická a léčivá chemie. 10 (12): 4119–29. doi:10.1016 / s0968-0896 (02) 00331-0. PMID 12413866.
- ^ A b C d E F G Wiley JL, Smith VJ, Chen J, Martin BR, Huffman JW (2012). "Syntéza a farmakologie 1-alkyl-3- (1-naftoyl) indolů: Sterické a elektronické účinky 4- a 8-halogenovaných naftoylových substituentů". Bioorganická a léčivá chemie. 20 (6): 2067–2081. doi:10.1016 / j.bmc.2012.01.038. PMC 3298571. PMID 22341572.
- ^ Kanabinoidní receptory. Receptory. 2009. doi:10.1007/978-1-59745-503-9. ISBN 978-1-58829-712-9.